The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …

Abstract Objective Long-Segment Hirschsprung Disease (LSHD) differs clinically from short-
segment disease. This review article critically appraises current literature on the definition …

Cell therapy offers the potential to replace the missing enteric nervous system (ENS) in
patients with Hirschsprung disease (HSCR) and to restore gut function. The Schwann cell …

Enteric neural stem cell (ENSC) therapy offers great promise for neurointestinal diseases;
however, current isolation methods yield insufficient neurons for regenerative applications …

Interplay between embryonic enteric neural stem cells (ENSCs) and enteric mesenchymal
cells (EMCs) in the embryonic gut is essential for normal development of the enteric nervous …

Neurocristopathies form a heterogeneous group of rare diseases caused by abnormal
development of neural crest cells. Heterogeneity of neurocristopathies directly relates to the …

Despite significant progress in our understanding of the etiology and pathophysiology of
Hirschsprung disease (HSCR), early and accurate diagnosis and operative management …

Background Spinal cord injury (SCI) presents a significant challenge for the field of
neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury …

The gastrointestinal (GI) tract is imperative for multiple functions including digestion, nutrient
absorption, and timely waste disposal. The central feature of the gut is peristalsis, intestinal …

The enteric nervous system (ENS), known as the intrinsic nervous system of the
gastrointestinal tract, is composed of a diverse array of neuronal and glial cell subtypes …