The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating
breast. NIS mRNA and protein expression are detected in most thyroid cancer specimens …

Differentiated thyroid cancer and breast cancer account for a significant portion of endocrine-
related malignancies and predominately affect women. As hormonally responsive tissues …

Molecular iodine (I 2) is known to inhibit the induction and promotion of N-methyl-n-
nitrosourea-induced mammary carcinogenesis, to regress 7, 12-dimethylbenz (a) …

The protective effects of iodine on breast cancer have been postulated from epidemiologic
evidence and described in animal models. The molecular mechanisms responsible have not …

Purpose: Nasolacrimal outflow obstruction has been associated with high-dose (> 150 mCi)
radioactive iodine (I 131) treatment. Commonly used for thyroid cancer treatment, I 131 is …

Background Human sodium iodide symporter (hNIS) gene over-expression is under active
consideration worldwide as an alternative target molecule for breast cancer (BC) diagnosis …

Background Expression and function of sodium iodide symporter (NIS) is requisite for
efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of …

Purpose Radionuclide therapy (RNT) is a rapidly growing area of clinical nuclear medicine,
wherein radionuclides are employed to deliver cytotoxic dose of radiation to the diseased …

Objective The active transport of iodide into thyroid cells is mediated by the Na+/I− symporter
(NIS) located in the basolateral membrane. Strong intracellular staining with anti-NIS …

A number of solute carrier (SLC) proteins are subject to changes in expression and activity
during carcinogenesis. Whether these changes play a role in carcinogenesis is unclear …