Sex differences in biological aging with a focus on human studies

S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Sex‐specific aging in animals: perspective and future directions

AM Bronikowski, RP Meisel, PR Biga, JR Walters… - Aging …, 2022 - Wiley Online Library
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Decline in telomere length with increasing age across nonhuman vertebrates: A meta‐analysis

F Remot, V Ronget, H Froy, B Rey… - Molecular …, 2022 - Wiley Online Library
The prediction that telomere length (TL) shortens with increasing age is a major element in
considering the role of telomeres as a key player in evolution. While telomere attrition is …

Longer telomeres during early life predict higher lifetime reproductive success in females but not males

BJ Heidinger, AC Kucera… - Proceedings of the …, 2021 - royalsocietypublishing.org
The mechanisms that contribute to variation in lifetime reproductive success are not well
understood. One possibility is that telomeres, conserved DNA sequences at chromosome …

Longitudinal telomere dynamics within natural lifespans of a wild bird

ML Pepke, T Kvalnes, J Wright, YG Araya-Ajoy… - Scientific Reports, 2023 - nature.com
Telomeres, the nucleotide sequences that protect the ends of eukaryotic chromosomes,
shorten with each cell division and telomere loss may be influenced by environmental …

Cross-tissue comparison of telomere length and quality metrics of DNA among individuals aged 8 to 70 years

SE Wolf, WJ Hastings, Q Ye, L Etzel, AT Apsley… - Plos one, 2024 - journals.plos.org
Telomere length (TL) is an important biomarker of cellular aging, yet its links with health
outcomes may be complicated by use of different tissues. We evaluated within-and between …

Telomeres and telomerase: Active but complex players in life-history decisions

RČ Frydrychová, B Konopová, V Peska, M Brejcha… - Biogerontology, 2024 - Springer
Studies on human telomeres have established that telomeres exert a significant influence on
lifespan and health of organisms. However, recent research has indicated that the original …

Lifespan and telomere length variation across populations of wild‐derived African killifish

M Reichard, K Giannetti, T Ferreira… - Molecular …, 2022 - Wiley Online Library
Telomeres and telomerase prevent the continuous erosion of chromosome‐ends caused by
lifelong cell division. Shortened telomeres are associated with age‐related pathologies …

Sex and early-life conditions shape telomere dynamics in an ectotherm

A Hansson, E Wapstra, GM While… - Journal of …, 2024 - journals.biologists.com
Telomeres, the repetitive DNA regions that protect the ends of chromosomes, and their
shortening have been linked to key life history trade-offs among growth, reproduction and …

Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length

ED Tichy, JH Lee, G Li, KN Estep, F Brad Johnson… - npj …, 2023 - nature.com
Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity.
Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to …