Mounting evidence has firmly established that low levels of cardiorespiratory fitness (CRF)
are associated with a high risk of cardiovascular disease, all-cause mortality, and mortality …

This review focuses on how blood flow to contracting skeletal muscles is regulated during
exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in …

Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic
disorder characterized by an excessive heart rate increase on standing and orthostatic …

In this review, we argue that several key features of maximal oxygen uptake (VO2max)
should underpin discussions about the biological and reductionist determinants of its …

The integrity and composition of the tumour microenvironment (TME) is highly plastic,
undergoing constant remodelling in response to instructive signals derived from alterations …

This review presents lower body negative pressure (LBNP) as a unique tool to investigate
the physiology of integrated systemic compensatory responses to altered hemodynamic …

Aerobic exercise training leads to cardiovascular changes that markedly increase aerobic
power and lead to improved endurance performance. The functionally most important …

Background Perioperative fluid therapy remains a highly debated topic. Its purpose is to
maintain or restore effective circulating blood volume during the immediate perioperative …

Orthostatic intolerance (OI), having difficulty tolerating an upright posture because of
symptoms or signs that abate when returned to supine, is common in pediatrics. For …

Importance Many patients with post-COVID condition (PCC) experience persistent fatigue,
muscle pain, and cognitive problems that worsen after exertion (referred to as postexertional …