Distinct roles for motor cortical and thalamic inputs to striatum during motor skill learning and execution

SBE Wolff, R Ko, BP Ölveczky - Science advances, 2022 - science.org
The acquisition and execution of motor skills are mediated by a distributed motor network,
spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog …

[HTML][HTML] High-density single-unit human cortical recordings using the Neuropixels probe

JE Chung, KK Sellers, MK Leonard, L Gwilliams, D Xu… - Neuron, 2022 - cell.com
The action potential is a fundamental unit of neural computation. Even though significant
advances have been made in recording large numbers of individual neurons in animal …

A cerebellar-thalamocortical pathway drives behavioral context-dependent movement initiation

J Dacre, M Colligan, T Clarke, JJ Ammer, J Schiemann… - Neuron, 2021 - cell.com
Executing learned motor behaviors often requires the transformation of sensory cues into
patterns of motor commands that generate appropriately timed actions. The cerebellum and …

Mesodiencephalic junction GABAergic inputs are processed separately from motor cortical inputs in the basilar pons

AJ Khalil, HD Mansvelder, L Witter - Iscience, 2022 - cell.com
The basilar pontine nuclei (bPN) are known to receive excitatory input from the entire
neocortex and constitute the main source of mossy fibers to the cerebellum. Various …

Preconfigured cortico-thalamic neural dynamics constrain movement-associated thalamic activity

P González-Pereyra, MG Martínez-Montalvo… - bioRxiv, 2023 - biorxiv.org
Neural preconfigured activity patterns (nPAPs) have been proposed as building blocks for
cognitive and sensory processing. However, their existence and function in motor networks …

Spatiotemporal organization of movement-invariant and movement-specific signaling in the output layer of motor cortex

SP Currie, JJ Ammer, B Premchand, J Dacre, Y Wu… - bioRxiv, 2020 - biorxiv.org
Motor cortex generates descending output necessary for executing a wide range of limb
movements. Although movement-related activity has been described throughout motor …