Understanding how the brain functions is one of the grand challenges in modern scientific
research. Similar to a computer, a functional brain is composed of hardware and software …

For decades, the spatial resolution of conventional far‐field optical imaging has been
constrained due to the diffraction limit. The emergence of optical super‐resolution imaging …

Two‐photon‐absorption‐induced photoluminescence (TPL) from nanostructures is
generally inefficient since it is a typical third‐order nonlinear optical process. Herein, a …

Stimulated Raman-scattering (SRS) microscopy has emerged as a powerful tool for
quantitative vibrational imaging of live tissues and cells with biochemical specificity, but the …

We present a technique for improving the spatial resolution of two-photon excitation
microscopy; our technique combines annular illumination with an in situ estimation of the …

The role of angiogenesis in health and disease have gained considerable momentum in
recent years. Visualizing angiogenic patterns and associated events of surrounding vascular …

We report a method to increase the efficiency of detecting nonlinear fluorescence signals in
saturated excitation (SAX) microscopy. With this method, we compare fluorescence signals …

Saturated excitation microscopy, which collects nonlinear fluorescence signals generated by
saturation, has been proposed to improve three-dimensional spatial resolution. Differential …

Super-resolution fluorescence microscopy is an important tool in biomedical research for its
ability to discern features smaller than the diffraction limit. However, due to its difficult …

Nonlinear optical effects modify the point spread function (PSF) in laser scanning
microscopy and have been utilized to enhance the spatial resolution in three dimensions. In …