Molecular diagnostics has generated substantial dividends in dissecting the genetic basis of
myeloid neoplasms with eosinophilia. The family of diseases generated by dysregulated …

Blood eosinophilia signifies either a cytokine‐mediated reactive phenomenon (secondary)
or an integral phenotype of an underlying haematological neoplasm (primary). Secondary …

The 8p11 myeloproliferative syndrome is an aggressive neoplasm associated with
chromosomal translocations involving the fibroblast growth factor receptor 1 tyrosine kinase …

In a registry-based analysis of 135 patients with “myeloid/lymphoid neoplasms with
eosinophilia and tyrosine kinase gene fusions”(MLN-TK; FIP1L1:: PDGFRA, n= 78; …

Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that
feature enhanced proliferation and survival of one or more myeloid lineage cells. William …

The 8p11 myeloproliferative syndrome (EMS) also known as stem cell leukemia-lymphoma
syndrome (SCLL) is associated with translocations that disrupt FGFR1. The resultant fusion …

• Introduction‐BCR‐ABL1‐ABL1‐BCR‐ABL1‐Anti‐BCR‐ABL1 targeted therapy in CML‐
Imatinib resistance and second‐generation anti‐BCR‐ABL1 kinase inhibitors‐Other ABL1 …

Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare
diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to …

Objectives Translocations involving the fibroblast growth factor receptor 1 (FGFR 1) gene
are associated with the 8p11 myeloproliferative syndrome (EMS), a rare neoplasm that …

We report the case of a child who presented with nonspecific symptoms suggestive of a
rheumatologic disorder, whose bone marrow had a complex translocation involving the …