Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

Articular cartilage defects are prevalent and are potentially involved in the initiation of
osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents …

Bone has a high potential for endogenous self-repair. However, due to population aging,
human diseases with impaired bone regeneration are on the rise. Current strategies to …

Early vascularized soft-tissue closure has long been recognized to be essential in achieving
eventual infection-free union. The question of whether muscle or fasciocutaneous tissue is …

Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic
strategy. Among its advantages over protein delivery are the potential for directed, sustained …

Introduction Transplantation of genetically modified human bone marrow-derived
mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation …

Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and
remain a clinical challenge. Healing such defects requires the formation of large amounts of …

Gene therapy has converged with bone engineering over the past decade, by which a
variety of therapeutic genes have been delivered to stimulate bone repair. These genes can …

With the increasing application of microRNAs (miRNAs) in the treatment and monitoring of
different diseases, miRNAs have become an important tool in biological and medical …