Altered pronociceptive and antinociceptive mechanisms are often implicated in painful
conditions and have been increasingly studied over the past decade. For some painful …

Importance Effective treatments for chronic spinal pain are essential to reduce the related
high personal and socioeconomic costs. Objective To compare pain neuroscience …

This systematic review and meta-analysis examined the evidence for altered central pain
processing in people with nontraumatic neck pain and the relationship among central pain …

Pain normally signals a threat to bodily integrity and causes emotional distress. Acute pain
serves a protective function, yet, when pain turns chronic, the protective function is lost. A …

Low back pain (LBP) has been inconsistently associated with enhanced pronociceptive and
impaired antinociceptive mechanisms. It remains unknown whether alterations are causal …

Objective Given the complex and unclear etiology of neck pain, it is important to understand
the differences in central sensitization as well as psychosocial factors in individuals with …

Objectives: Youth with functional abdominal pain (FAP) experience significant pain-related
distress and functional impairment. Although quantitative sensory testing protocols have …

In patients with neck pain, it is unclear whether pain inhibition and facilitation endogenous
pain mechanisms are altered. This systematic review and meta-analysis aimed to improve …

Persistent pain conditions, including low back pain (LBP), are often accompanied by
alterations in pronociceptive and antinociceptive mechanisms, as quantified by temporal …

Objectives Office workers with chronic neck pain demonstrates signs of widespread
hyperalgesia, less efficient descending pain modulation, which could indicate sensitization …