Significance: Vitamin C, or ascorbic acid, has long been known to participate in several
important functions in the vascular bed in support of endothelial cells. These functions …

Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The
principal evidence behind how they increase vascular permeability in vivo and in vitro and …

Distant metastasis, which results in> 90% of cancer-related deaths, is enabled by
hematogenous dissemination of tumor cells via the circulation. This requires the completion …

Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although
significant progress has been made in visualizing tumor cell motility in vivo, the underlying …

The vascular system has the critical function of supplying tissues with nutrients and clearing
waste products. To accomplish these goals, the vasculature must be sufficiently permeable …

Abstract Human colon adenocarcinoma (Caco-2) cells, when grown on semipermeable
filters, spontaneously differentiate in culture to form confluent monolayers which both …

This work describes the formation, perfusion, and maturation of three-dimensional
microvascular tubes in vitro. These tubes consisted of confluent monolayers of human …

This review addresses classical questions concerning microvascular permeabiltiy in the light
of recent experimental work on intact microvascular beds, single perfused microvessels, and …

The bulk of aqueous humour outflow resistance is generated in or near the inner wall
endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes …

Encapsulation of microRNAs in exosomes confers protection against degradation and a
vehicle for shuttling of microRNAs between cells and tissues, and cellular uptake by …