Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

T cells, the critical immune cells of the adaptive immune system, are often dysfunctional in
Alzheimer's disease (AD) and are involved in AD pathology. Reports highlight …

Tissue-resident memory T cells (TRM cells) in the airways mediate protection against
respiratory infection. We characterized TRM cells expressing integrin αE (CD103) that reside …

Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …

Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue
architecture. In addition, they regulate lymphocyte compartmentalization through the …

During the last 10 years, a population of clonally expanded T cells that take up permanent
residence in non-lymphoid tissues has been identified. The localization of these tissue …

CD4+ T cells differentiate into memory T cells that protect the host from subsequent infection.
In contrast, autoreactive memory CD4+ T cells harm the body by persisting in the tissues …

Summary Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role
in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or …

Two models are proposed to explain Notch function during helper T (Th) cell differentiation.
One argues that Notch instructs one Th cell fate over the other, whereas the other posits that …

The evolutionarily conserved Notch signalling pathway regulates the differentiation and
function of mature T lymphocytes with major context-dependent consequences in host …