Bladder cancer is among the ten most common cancers globally, causes considerable
morbidity and mortality and is, therefore, a substantial burden for health-care systems. The …

Context Bladder cancer (BC) represents a significant health problem due to the potential
morbidity and mortality associated with disease burden, which has remained largely …

Importance Bladder cancer is a common malignancy in women and is the fourth most
common malignancy in men. Bladder cancer ranges from unaggressive and usually …

This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)
for Bladder Cancer focuses on the clinical presentation and workup of suspected bladder …

Overtreatment with cisplatin-based chemotherapy is a major issue in the management of
muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for …

Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and
associated with a poor prognosis. With a high mutation load and large number of altered …

Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …

Importance Knowledge about the spectrum of diseases associated with hereditary cancer
syndromes may improve disease diagnosis and management for patients and help to …

DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of
genetic material. However, different endogenous and exogenous factors challenge genomic …

The aims of the Prospective Lynch Syndrome Database (PLSD) are to provide empirical
prospectively observed data on the incidences of cancer in different organs, survival …