The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

Graph machine learning (GML) is receiving growing interest within the pharmaceutical and
biotechnology industries for its ability to model biomolecular structures, the functional …

Targeted protein degradation allows targeting undruggable proteins for therapeutic
applications as well as eliminating proteins of interest for research purposes. While several …

Functional genomics efforts face tradeoffs between number of perturbations examined and
complexity of phenotypes measured. We bridge this gap with Perturb-seq, which combines …

Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Gene silencing is instrumental to interrogate gene function and holds promise for
therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing …

Genome editing (GE) has revolutionized the biological sciences by creating a novel
approach for manipulating the genomes of living organisms. Many tools have been …

Background The development of CRISPR/Cas9 technology has facilitated targeted
mutagenesis in an efficient and precise way. Previously, RNAi silencing of the susceptibility …

Developing technologies for efficient and scalable disruption of gene expression will provide
powerful tools for studying gene function, developmental pathways, and disease …

Hybrid rice breeding offers an important strategy to improve rice production, in which the
cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 …