Cancer remains the second leading cause of death in the US, accounting for 25% of all
deaths nationwide. Immunotherapy techniques bolster the immune cells' ability to target …

Chimeric antigen receptor (CAR) technologies have been clinically implemented for the
treatment of hematological malignancies; however, solid tumors remain resilient to CAR …

Abstract Human Adenoviruses (HAdV) are nearly ubiquitous pathogens comprising
numerous sub-types that infect various tissues and organs. Among many encoded proteins …

SIGIRR (single immunoglobulin IL‐1 related receptor), PKP3 (plakophilin 3), and TMEM16J
(anoctamin 9), a putative calcium‐activated ion channel and phospholipid scramblase …

Background: De novo variants (DNVs) are currently not routinely evaluated as part of
diagnostic whole exome sequencing (WES) analysis in patients with suspected inborn …

Proteins containing PDZ (post-synaptic density, PSD-95/disc large, Dlg/zonula occludens,
ZO-1) domains assemble signaling complexes that orchestrate cell responses. Viral …

Background Celiac disease (CD) is a chronic autoimmune disorder characterized by an
abnormal immune response to gluten, a protein found in wheat, barley, and rye. It is well …

Apicobasal polarity is a hallmark of retinal pigment epithelium cells and is required to
perform their functions; however, the precise roles of the different proteins that execute …

Cancer immunotherapies represent an emergent yet powerful therapeutic paradigm, due to
both their durable clinical responses and their applicability to a wide variety of tumors …

Mitochondrial dynamics are emerging as master regulators for targeting several types of
cancers, including breast cancer, cervical cancer, and hepatocellular carcinoma, for …