Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice
D Luckey, D Bastakoty, AK Mangalam - Journal of autoimmunity, 2011 - Elsevier
Multiple sclerosis (MS), an inflammatory and demyelinating autoimmune disease of CNS
has both, a genetic and an environmental predisposition. Among all the genetic factors …
has both, a genetic and an environmental predisposition. Among all the genetic factors …
The conundrum of iron in multiple sclerosis–time for an individualised approach
SJ van Rensburg, MJ Kotze, R Van Toorn - Metabolic brain disease, 2012 - Springer
Although the involvement of immune mechanisms in multiple sclerosis (MS) is undisputed,
some argue that there is insufficient evidence to support the hypothesis that MS is an …
some argue that there is insufficient evidence to support the hypothesis that MS is an …
Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians
SM Orton, SV Ramagopalan, AE Para… - Journal of the …, 2011 - Elsevier
BACKGROUND: Multiple sclerosis (MS) is determined by interactions between genes and
environment and the influence of vitamin D adequacy has been proposed. Previous studies …
environment and the influence of vitamin D adequacy has been proposed. Previous studies …
The evaluation of VEGF and HIF‐1α gene polymorphisms and multiple sclerosis susceptibility
Background Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath
destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing …
destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing …
Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients
Recent association studies in multiple sclerosis (MS) have identified and replicated several
single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R …
single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R …
Genetic modifiers of multiple sclerosis progression, severity and onset
AD Sadovnick, AL Traboulsee, Y Zhao, CQ Bernales… - Clinical …, 2017 - Elsevier
The genetic contribution to clinical outcomes for multiple sclerosis (MS) has yet to be
defined. We performed exome sequencing analysis in 100 MS patients presenting opposite …
defined. We performed exome sequencing analysis in 100 MS patients presenting opposite …
A genetic basis for multiple sclerosis severity: Red herring or real?
VG Jokubaitis, H Butzkueven - Molecular and cellular probes, 2016 - Elsevier
Multiple Sclerosis (MS) is an autoimmune degenerative disease of the central nervous
system, characterized by multifocal demyelination and neurodegeneration. The genetic …
system, characterized by multifocal demyelination and neurodegeneration. The genetic …
HLA-DQ8 (DQB1* 0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice
A Mangalam, D Luckey, E Basal, M Jackson… - The Journal of …, 2009 - journals.aai.org
Among all of the genetic factors associated with multiple sclerosis (MS) susceptibility, MHC
class II molecules have the strongest association. Although a direct role of DR alleles in MS …
class II molecules have the strongest association. Although a direct role of DR alleles in MS …
Gene variants of adhesion molecules predispose to MS: A case-control study
Objective To examine the effect of variants in genes encoding molecules that are implicated
in leukocyte trafficking into the CNS on the development of MS. Methods A total of 389 Greek …
in leukocyte trafficking into the CNS on the development of MS. Methods A total of 389 Greek …
Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS that affects around one
million people in the United States. Predisposition or protection from this disease is linked …
million people in the United States. Predisposition or protection from this disease is linked …