Adaptive immune responses to primary and secondary dengue virus infections

AL St. John, APS Rathore - Nature Reviews Immunology, 2019 - nature.com
Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the
circulation of multiple serotypes, global expansion of the disease and recent gains in …

The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design

FA Rey, K Stiasny, MC Vaney, M Dellarole… - EMBO reports, 2018 - embopress.org
Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically
related viruses that cause significant arthropod‐transmitted diseases throughout the globe …

Separable microneedle patch to protect and deliver DNA nanovaccines against COVID-19

Y Yin, W Su, J Zhang, W Huang, X Li, H Ma, M Tan… - ACS …, 2021 - ACS Publications
The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying
on the development of vaccines, but also depending on the storage, transportation, and …

Structural basis of Zika virus-specific antibody protection

H Zhao, E Fernandez, KA Dowd, SD Speer, DJ Platt… - Cell, 2016 - cell.com
Zika virus (ZIKV) infection during pregnancy has emerged as a global public health problem
because of its ability to cause severe congenital disease. Here, we developed six mouse …

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry

L Meertens, X Carnec, MP Lecoin, R Ramdasi… - Cell host & …, 2012 - cell.com
Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases.
However, the molecular interactions mediating DV entry are poorly understood. We …

Antibody-dependent enhancement: a challenge for developing a safe dengue vaccine

R Shukla, V Ramasamy, RK Shanmugam… - Frontiers in cellular …, 2020 - frontiersin.org
In 2019, the United States Food and Drug Administration accorded restricted approval to
Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito …

Structural biology of Zika virus and other flaviviruses

SS Hasan, M Sevvana, RJ Kuhn… - Nature structural & …, 2018 - nature.com
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …

A broadly protective antibody that targets the flavivirus NS1 protein

N Modhiran, H Song, L Liu, C Bletchly, L Brillault… - Science, 2021 - science.org
There are no approved flaviviral therapies and the development of vaccines against
flaviruses has the potential of being undermined by antibody-dependent enhancement …

The antigenic structure of Zika virus and its relation to other flaviviruses: implications for infection and immunoprophylaxis

FX Heinz, K Stiasny - Microbiology and Molecular Biology …, 2017 - Am Soc Microbiol
Zika virus was discovered∼ 70 years ago in Uganda and maintained a low profile as a
human disease agent in Africa and Asia. Only recently has it caused explosive outbreaks in …

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

A Rouvinski, P Guardado-Calvo, G Barba-Spaeth… - Nature, 2015 - nature.com
Dengue disease is caused by four different flavivirus serotypes, which infect 390 million
people yearly with 25% symptomatic cases and for which no licensed vaccine is available …