Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints.
Neutrophils are believed to play an important role in both the initiation and progression of …

The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …

Of all cells implicated in the pathology of rheumatoid arthritis (RA), neutrophils possess the
greatest cytotoxic potential, owing to their ability to release degradative enzymes and …

Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …

Summary Interleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune
system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it …

Abstract Background The Janus kinase (JAK) family of tyrosine kinases includes JAK1,
JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine …

Interleukin (IL)-17A has a direct contribution in early induction and late chronic stages of
various inflammatory diseases. In vitro and in vivo experiments have first characterized its …

Inflammatory conditions in some tissues increase the risk of cancer. Cytokines and
chemokines are components of an intensive dialog promoting angiogenesis, metastasis …