BACKGROUND: There is a need for more research on all forms of rhinosinusitis. Progress in
this area has been hampered by a lack of consensus definitions and the limited number of …

abstract Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local
inflammation of the upper airways and sinuses which persists for at least 12 weeks. CRS …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

Rationale: The mechanisms that underlie the pathogenesis of chronic rhinosinusitis without
nasal polyps (CRSsNP), chronic rhinosinusitis with nasal polyps (CRSwNP), and aspirin …

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the
accumulation of inflammatory cells; however, an eosinophil predominance is seen in white …

Nasal polyposis (NP) is a chronic inflammatory condition that is mostly characterized by an
infiltration of eosinophils. How this eosinophilic inflammation leads to polyp formation …

The airway epithelial cell is the initial cell type impacted both by inhaled environmental
factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway …

Background: Environmental factors such as inhaled pollutants like cigarette smoke may play
a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced, irradiated
tumor vaccines induce potent, T-cell-mediated antitumor immune responses in preclinical …