The microenvironment (local environment), including viscosity, temperature, polarity,
hypoxia, and acidic-basic status (pH), plays indispensable roles in cellular processes …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance
is largely unknown. Here, we show that lean mice become insulin resistant after being …

For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Phospholipids are major constituents of biological membranes. The fatty acyl chain
composition of phospholipids determines the biophysical properties of membranes and …

Many thousands of lipid species exist and their metabolism is interwoven via numerous
pathways and networks. These networks can also change in response to cellular …

Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …