Cardiac cell modelling: observations from the heart of the cardiac physiome project
In this manuscript we review the state of cardiac cell modelling in the context of international
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …
The cell physiome: what do we need in a computational physiology framework for predicting single-cell biology?
Modern biology and biomedicine are undergoing a big data explosion, needing advanced
computational algorithms to extract mechanistic insights on the physiological state of living …
computational algorithms to extract mechanistic insights on the physiological state of living …
Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes
The contractile properties of cardiac myocytes depend on the calcium (Ca 2+) released by
clusters of ryanodine receptors (RyRs) throughout the myoplasm. Accurate quantification of …
clusters of ryanodine receptors (RyRs) throughout the myoplasm. Accurate quantification of …
Organization of ryanodine receptors, transverse tubules, and sodium-calcium exchanger in rat myocytes
Confocal and total internal reflection fluorescence imaging was used to examine the
distribution of caveolin-3, sodium-calcium exchange (NCX) and ryanodine receptors (RyRs) …
distribution of caveolin-3, sodium-calcium exchange (NCX) and ryanodine receptors (RyRs) …
Three-dimensional and chemical mapping of intracellular signaling nanodomains in health and disease with enhanced expansion microscopy
TMD Sheard, ME Hurley, J Colyer, E White… - ACS …, 2019 - ACS Publications
Nanodomains are intracellular foci which transduce signals between major cellular
compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) …
compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) …
[HTML][HTML] A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum …
MA Colman, C Pinali, AW Trafford… - PLoS computational …, 2017 - journals.plos.org
Intracellular calcium cycling is a vital component of cardiac excitation-contraction coupling.
The key structures responsible for controlling calcium dynamics are the cell membrane …
The key structures responsible for controlling calcium dynamics are the cell membrane …
Size matters: ryanodine receptor cluster size heterogeneity potentiates calcium waves
Ryanodine receptors (RyRs) mediate calcium (Ca)-induced Ca release and intracellular Ca
homeostasis. In a cardiac myocyte, RyRs group into clusters of variable size from a few to …
homeostasis. In a cardiac myocyte, RyRs group into clusters of variable size from a few to …
Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells
MD Stern, LA Maltseva, M Juhaszova… - Journal of General …, 2014 - rupress.org
The sinoatrial node, whose cells (sinoatrial node cells [SANCs]) generate rhythmic action
potentials, is the primary pacemaker of the heart. During diastole, calcium released from the …
potentials, is the primary pacemaker of the heart. During diastole, calcium released from the …
Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation
To meet high cellular demands, the energy metabolism of cardiac muscles is organized by
precise and coordinated functioning of intracellular energetic units (ICEU s). ICEU s …
precise and coordinated functioning of intracellular energetic units (ICEU s). ICEU s …
Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes
Spatio-temporal dynamics of intracellular calcium,[Ca2+] i, regulate the contractile function
of cardiac muscle cells. Measuring [Ca2+] i flux is central to the study of mechanisms that …
of cardiac muscle cells. Measuring [Ca2+] i flux is central to the study of mechanisms that …