Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi - Pharmacological Reviews, 2021 - ASPET
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

T Prévot, E Sibille - Molecular psychiatry, 2021 - nature.com
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …

Ketamine and depression: a narrative review

A Corriger, G Pickering - Drug design, development and therapy, 2019 - Taylor & Francis
Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …

[HTML][HTML] Glutamate and GABA homeostasis and neurometabolism in major depressive disorder

A Sarawagi, ND Soni, AB Patel - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives

C Fee, M Banasr, E Sibille - Biological psychiatry, 2017 - Elsevier
The functional integration of external and internal signals forms the basis of information
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …

Gannet: A batch‐processing tool for the quantitative analysis of gamma‐aminobutyric acid–edited MR spectroscopy spectra

RAE Edden, NAJ Puts, AD Harris… - Journal of magnetic …, 2014 - Wiley Online Library
Purpose The purpose of this study is to describe the Gannet toolkit for the quantitative batch
analysis of gamma‐aminobutyric acid (GABA)‐edited MRS data. Materials and Methods …

Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder

CC Streeter, PL Gerbarg, RB Saper, DA Ciraulo… - Medical hypotheses, 2012 - Elsevier
A theory is proposed to explain the benefits of yoga practices in diverse, frequently comorbid
medical conditions based on the concept that yoga practices reduce allostatic load in stress …

Brain GABA levels across psychiatric disorders: A systematic literature review and meta‐analysis of 1H‐MRS studies

RR Schür, LWR Draisma, JP Wijnen… - Human brain …, 2016 - Wiley Online Library
The inhibitory gamma‐aminobutyric acid (GABA) system is involved in the etiology of most
psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major …

The GABAergic deficit hypothesis of major depressive disorder

B Luscher, Q Shen, N Sahir - Molecular psychiatry, 2011 - nature.com
Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

The GABA system in anxiety and depression and its therapeutic potential

H Möhler - Neuropharmacology, 2012 - Elsevier
In the regulation of behavior, the role of GABA neurons has been extensively studied in the
circuit of fear, where GABA interneurons play key parts in the acquisition, storage and …