Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
developing and mature central nervous system (CNS) and its potential connections to …

This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Substantial evidence indicates that the lateral septum (LS) plays a critical role in regulating
processes related to mood and motivation. This review presents findings from the basic …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

The variability in phenotypic presentations and the lack of consistency of genetic
associations in mental illnesses remain a major challenge in molecular psychiatry. Recently …

Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …

In this report we describe findings that imply dysregulation of several fibroblast growth factor
(FGF) system transcripts in frontal cortical regions of brains from human subjects with major …

Reelin is a secreted glycoprotein that regulates neuronal positioning in cortical brain
structures through the VLDLR and ApoER2 receptors and the adaptor protein Dab1. In …