Newer antipsychotics introduced in clinical practice in recent years include clozapine,
risperidone, olanzapine, quetiapine, sertindole, ziprasidone, aripiprazole and amisulpride …

Until reports of interactions between St John's wort and drugs such as digoxin, warfarin,
protease inhibitors and oral contraceptives began to appear, very few herb-drug interactions …

Aims Guidance on clozapine dosing in treatment‐resistant schizophrenia is based largely
on data from White young adult males. This study aimed to investigate the pharmacokinetic …

Influence of Dose, Cigarette Smoking, Age, Sex, and Metaboli... : Journal of Clinical
Psychopharmacology Influence of Dose, Cigarette Smoking, Age, Sex, and Metabolic Activity on …

The Simcyp® Population-Based ADME Simulator was used to predict median drug
clearances and their associated variance from in vitro data. Fifteen drugs satisfied the entry …

Atypical antipsychotics [also known as second-generation antipsychotics (SGAs)] have
become a mainstay therapeutic treatment intervention for patients with schizophrenia …

The authors assessed the in vitro contribution of cytochrome P450 (CYP) isoforms 1A2, 3A4,
2C9, 2C19, and 2D6 to the N‐demethylation of clozapine mediated by human liver …

Osteoarthritis and sarcopenia are two major joint and skeletal muscle diseases prevalent
during aging. Osteoarthritis is a multifactorial progressive degenerative and inflammatory …

The psychotropic drug-drug interactions most likely to be relevant to psychiatrists' practices
are examined. The metabolism and the enzymatic and P-glycoprotein inhibition/induction …

Abstract Background and Objectives Although therapeutic drug monitoring of clozapine is
recommended, its optimisation is often adjusted only on the basis of dosage. The aim of this …