Perfusion of the renal medulla plays an important role in salt and water balance. Pericytes
are smooth muscle-like cells that impart contractile function to descending vasa recta (DVR) …

Urea is the most abundant solute in the urine in humans (on a Western-type diet) and
laboratory rodents. It is far more concentrated in the urine than in plasma and extracellular …

The neurodegenerative disorder Huntington's disease (HD) is typically characterized by
extensive loss of striatal neurons and the midlife onset of debilitating and progressive …

Urea recycling in ruminants has been studied extensively in the past, but the mechanisms
regulating the amount of urea recycled or excreted remain obscure. To elucidate the role of …

Urea transporter UT-B has been proposed to be the major urea transporter in erythrocytes
and kidney-descending vasa recta. The mouse UT-B cDNA was isolated and encodes a 384 …

The microcirculation of the renal medulla traps NaCl and urea deposited to the interstitium
by the loops of Henle and collecting ducts. Theories have predicted that countercurrent …

▪ Abstract Urea plays a key role in the urine-concentrating mechanism. Physiologic and
molecular data demonstrate that urea transport in kidney and red blood cells occurs by …

Maintaining a correct balance of N is essential for life. In mammals, the major sources of N in
the diet are amino acids and peptides derived from ingested proteins. The immediate …

We reported increased water permeability and a low urea reflection coefficient in Xenopus
oocytes expressing urea transporter UT-B (former name UT3), suggesting that water and …

Since the turn of the 21st century, gene knockout mice have been created for all major urea
transporters that are expressed in the kidney: the collecting duct urea transporters UT-A1 …