ContextIntense debate persists about the need for placebo-controlled groups in clinical trials
of medications for major depressive disorder (MDD). There is continuing interest in the …

In recent years, several authors have argued that placebo-controlled trials are invariably
unethical when known effective therapy is available for the condition being studied …

This is an excellent book, which will be of value to all those health professionals seeking to
demystify the sometimes intimidating area of research. Well organised, comprehensive, and …

INDICE: Generalidades. Variable epidemiológica. Medidas de frecuencia. Indicadores de
frecuencia de la morbimortalidad. Estrategia de la epidemiología y proceso de causalidad …

The debate on the ethics of international clinical research involving collaboration with
developing countries has achieved a high profile in recent years. Informed consent and …

ContextDuplicate publication is publication of an article that overlaps substantially with an
article published elsewhere. Patterns of duplication are not well understood. ObjectiveTo …

Objectives To examine the efficacy of respiratory physiotherapy for prevention of pulmonary
complications after abdominal surgery. Methods We searched in databases and …

Objectives: To compare patients' preference for transdermal fentanyl or sustained release
oral morphine, their level of pain control, and their quality of life after treatment. Design …

Objective To assess whether respiratory physiotherapy prevents pulmonary complications
after cardiac surgery. Data sources Searches through Medline, Embase, Cinahl, the …

Purpose: To estimate the efficacy and harm produced by droperidol in the prevention of
postoperative nausea and vomiting (PONV). Methods: Systematic search (MEDLINE …