Activated factor VII (FVIIa), the first protease of clotting, expresses its physiological
procoagulant potential only after complexing with tissue factor (TF) exposed to blood. Deep …

Factor VII deficiency is the most common among rare inherited autosomal recessive
bleeding disorders, and is a chameleon disease due to the lack of a direct correlation …

Introduction The rare coagulation disorders may present significant difficulties in diagnosis
and management. In addition, considerable inter‐individual variation in bleeding phenotype …

Introduction Women and girls affected by haemophilia, including haemophilia carriers
(WGH) are at risk of bleeding symptoms that may go unrecognized, including heavy …

Rare bleeding disorders (RBDs) are a heterogeneous group of coagulation factor
deficiencies that include fibrinogen, prothrombin, α 2-antiplasmin, plasminogen activator …

Factor VII (FVII) deficiency is the most common of the Rare Inherited Coagulation Disorders.
The inheritance is autosomal recessive but there is variable penetrance. Overall there is …

Abstract Background Congenital factor VII (FVII) deficiency is an inherited bleeding disorder,
with heterogenous bleeding symptoms. Women with FVII deficiency face hemostatic …

Coagulation factors belong to a family of plasma glycosylated proteins that should be
activated for appropriate blood coagulation. Congenital deficiencies of these factors cause …

Introduction Inherited factor VII deficiency is the most common autosomal recessive inherited
bleeding disorder, with an estimated incidence of one per 500 000 cases in the general …

Blood coagulation comprises a series of enzymatic reactions leading to thrombin generation
and fibrin formation. This process is commonly illustrated in a waterfall-like manner, referred …