One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins
due to changes in proteostasis involving endoplasmic reticulum (ER) stress. To alleviate ER …

Autophagy is a highly controlled lysosome-mediated function in eukaryotic cells to eliminate
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Sepsis is an enormous public health issue and the leading cause of death in critically ill
patients in intensive care units. Overwhelming inflammation, characterized by cytokine …

Mild blast-induced traumatic brain injury (TBI) is associated with blood-brain barrier (BBB)
disruption. However, the mechanisms whereby blast disrupts BBB integrity are not well …

The PKR-like ER kinase (PERK), a transmembrane protein, resides in the endoplasmic
reticulum (ER). Its activation serves as a key sensor of ER stress, which has been implicated …

Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive
complications, including significantly increased risk of developing aging-related …

Blast-related traumatic brain injury (TBI) has received much recent attention because of its
frequency in the conflicts in Iraq and Afghanistan. This renewed interest has led to a rapid …

Much concern exists over the role of blast-induced traumatic brain injury (TBI) in the chronic
cognitive and mental health problems that develop in veterans and active duty military …

The brain and the retina share many physiological similarities, which allows the retina to
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …