Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of
UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Cellular DNA is subjected to continual attack, both by reactive species inside cells and by
environmental agents. Toxic and mutagenic consequences are minimized by distinct …

DNA double-strand breaks are repaired by multiple mechanisms that are roughly grouped
into the categories of homology-directed repair and non-homologous end joining. End …

Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore
plays a crucial role in preventing cancer. Repair studied at the level of transcription …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

Synonymous sites are generally assumed to be subject to weak selective constraint. For this
reason, they are often neglected as a possible source of important functional variation. We …

The RecQ helicases represent a subfamily of DNA helicases that are highly conserved in
evolution. Loss of RecQ helicase function leads to a breakdown in the maintenance of …

We have used genetic and microarray analysis to determine how ionizing radiation (IR)
induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces …

The recent sequencing of the Drosophila genome as a collaborative effort between the
Berkeley Drosophila Genome Project (BDGP) 1 and Celera Genomics provides an …