Hedgehog signaling mechanism and role in cancer
J Jiang - Seminars in cancer biology, 2022 - Elsevier
Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer
PP Adiseshaiah, RM Crist, SS Hook… - Nature reviews Clinical …, 2016 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related
deaths. PDAC remains one of the most difficult-to-treat cancers, owing to its unique …
deaths. PDAC remains one of the most difficult-to-treat cancers, owing to its unique …
[HTML][HTML] Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer
KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic
response that promotes hypovascularity, immunosuppression, and resistance to chemo-and …
response that promotes hypovascularity, immunosuppression, and resistance to chemo-and …
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to
patient mortality, yet antistromal therapies are controversial. We found that human PDACs …
patient mortality, yet antistromal therapies are controversial. We found that human PDACs …
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human
malignancies, with no truly effective therapies for advanced disease. Preclinical studies …
malignancies, with no truly effective therapies for advanced disease. Preclinical studies …
Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going
C Liang, S Shi, Q Meng, D Liang, S Ji… - … & molecular medicine, 2017 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …
Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer
The complex interplay between cancer cells and their microenvironment remains a major
challenge in the design and optimization of treatment strategies for pancreatic ductal …
challenge in the design and optimization of treatment strategies for pancreatic ductal …
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
A Neesse, S Krug, TM Gress, DA Tuveson… - OncoTargets and …, 2013 - Taylor & Francis
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat.
Over recent years, it has become increasingly evident that the complex network of soluble …
Over recent years, it has become increasingly evident that the complex network of soluble …
Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma
Background Herein, we investigate the relationship between pancreatic stem cell markers
(PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact …
(PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact …
ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy …
N Kawai, Y Hirohashi, Y Ebihara, T Saito, A Murai… - PLoS …, 2019 - journals.plos.org
Photodynamic diagnosis/therapy (PDD/PDT) are novel modalities for the diagnosis and
treatment of cancer. The photosensitizer protoporphyrin IX is metabolized from 5 …
treatment of cancer. The photosensitizer protoporphyrin IX is metabolized from 5 …