Cultivating multidisciplinarity: Manufacturing and sensing challenges in cultured meat production

M Djisalov, T Knežić, I Podunavac, K Živojević… - Biology, 2021 - mdpi.com
Simple Summary United Nations estimates that by the year 2050, the population of nearly 10
billion people will have 70% higher food demands than the current food systems can …

Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

MA MacDonald, M Nöbel… - Critical reviews in …, 2022 - Taylor & Francis
Much of the biopharmaceutical industry's success over the past 30 years has relied on
products derived from Chinese Hamster Ovary (CHO) cell lines. During this time …

Oxygen mass transfer in biopharmaceutical processes: numerical and experimental approaches

S Seidel, RW Maschke, S Werner… - Chemie Ingenieur …, 2021 - Wiley Online Library
Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper
presents the oxygen demand of different cells and summarizes experimental and numerical …

Heparan sulfate-collagen surface multilayers support serum-free microcarrier culture of mesenchymal stem cells

SJ Cifuentes, NA Theran-Suarez… - ACS Biomaterials …, 2024 - ACS Publications
The increasing cost of high-volume cultures and dependence on serum and growth factor
supplementation limit the affordability of mesenchymal stromal cell (MSC) therapies. This …

[HTML][HTML] Computational fluid dynamics modeling of cell cultures in bioreactors and its potential for cultivated meat production—A mini-review

FJC Rivera, J Chen - Future Foods, 2022 - Elsevier
Cultivated meat production was developed as a response to the rapidly increasing demand
for meat consumption. Bioreactor designs were adapted from other bioprocesses to account …

Machine learning analysis provides insight into mechanisms of protein particle formation inside containers during mechanical agitation

NG Thite, S Ghazvini, N Wallace, N Feldman… - Journal of …, 2022 - Elsevier
Container choice can influence particle generation within protein formulations.
Incompatibility between proteins and containers can manifest as increased particle …

Single-use bioreactors for human pluripotent and adult stem cells: towards regenerative medicine applications

DES Nogueira, JMS Cabral, CAV Rodrigues - Bioengineering, 2021 - mdpi.com
Research on human stem cells, such as pluripotent stem cells and mesenchymal stromal
cells, has shown much promise in their use for regenerative medicine approaches …

[HTML][HTML] Controlling Aspergillus niger morphology in a low shear-force environment in a rocking-motion bioreactor

T Kheirkhah, P Neubauer, S Junne - Biochemical Engineering Journal, 2023 - Elsevier
The filamentous fungus Aspergillus niger is an important production host in biotechnology.
Shear force regimes are one of the key factors that affect macromorphology and product …

CFD modelling of a wave-mixed bioreactor with complex geometry and two degrees of freedom motion

S Seidel, RW Maschke, M Kraume, R Eibl… - Frontiers in Chemical …, 2022 - frontiersin.org
Optimizing bioprocesses requires an in-depth understanding, from a bioengineering
perspective, of the cultivation systems used. A bioengineering characterization is typically …

Vibration energy transfer in a forced oscillation fluidized bed

Y Li, K Hong, C Zhou, Y Zhao, C Duan… - Chemical Engineering …, 2023 - Elsevier
Fluidized bed technology plays a vital role in petroleum, chemical, and coal separation. To
improve fluidization stability, airflow is periodically introduced to form a pulsed gas–solid …