The production of sufficient quantities of homogenous protein not only is an essential
prelude for structural investigations but also represents a rate-limiting step for many human …

The rapid evolution of influenza virus makes antiviral drugs less effective, which is
considered to be a major bottleneck in antiviral therapy. The key proteins in the host cells …

Since its inception more than 30 years ago, the baculovirus expression vector system
(BEVS) has been used prolifically to produce heterologous proteins for research and …

Abstract The coronavirus disease-2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health …

The cloning of the large DNA genomes of herpesviruses, poxviruses, and baculoviruses as
bacterial artificial chromosomes (BAC) in Escherichia coli has opened a new era in viral …

Baculoviruses have very large genomes and previous studies have demonstrated
improvements in recombinant protein production and genome stability through the removal …

Background Crimean-Congo hemorrhagic fever virus (CCHFV) is a member of the
nairovirus, a genus in the Bunyaviridae family, which causes a life threatening disease in …

Introduction: Antiviral therapy is an alternative for viral infection control when the virus is
identified. As antiviral therapy has effectively used basic science to create very efficient …

Small-molecule drugs have dominated the pharmaceutical industry and physician's
prescription pads since the beginning of modern medicine. The most recent decades …

Introduction: Antiviral therapy is an alternative for viral infection control when the virus is
identified. As antiviral therapy has effectively used basic science to create very efficient …