Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
The ever-evolving role of mTOR in translation
Control of translation allows for the production of stoichiometric levels of each protein in the
cell. Attaining such a level of fine-tuned regulation of protein production requires the …
cell. Attaining such a level of fine-tuned regulation of protein production requires the …
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …
Structure of the voltage-gated calcium channel Cav1.1 complex
INTRODUCTION Voltage-gated Ca2+ (Cav) channels activate in response to membrane
potential changes and initiate Ca2+-mediated cellular signaling cascades. The L-type, high …
potential changes and initiate Ca2+-mediated cellular signaling cascades. The L-type, high …
Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Y Wu, Y Zhu, F Gao, Y Jiao… - Proceedings of the …, 2017 - National Acad Sciences
Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus
(RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause …
(RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause …
Dissecting diazirine photo-reaction mechanism for protein residue-specific cross-linking and distance mapping
Y Jiang, X Zhang, H Nie, J Fan, S Di, H Fu… - Nature …, 2024 - nature.com
While photo-cross-linking (PXL) with alkyl diazirines can provide stringent distance restraints
and offer insights into protein structures, unambiguous identification of cross-linked residues …
and offer insights into protein structures, unambiguous identification of cross-linked residues …
Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer
AC Rutkovsky, ES Yeh, ST Guest, VJ Findlay… - Bmc Cancer, 2019 - Springer
Abstract Background Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is
overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in …
overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in …
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is
widely used to study protein-protein interactions (PPI), protein structures, and even protein …
widely used to study protein-protein interactions (PPI), protein structures, and even protein …
Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement
DT Setiaputra, DTH Cheng, S Lu, JM Hansen… - EMBO …, 2017 - embopress.org
Elongator is a~ 850 kDa protein complex involved in multiple processes from transcription to
tRNA modification. Conserved from yeast to humans, Elongator is assembled from two …
tRNA modification. Conserved from yeast to humans, Elongator is assembled from two …
RagC phosphorylation autoregulates mTOR complex 1
The mechanistic (or mammalian) target of rapamycin complex 1 (mTORC 1) controls cell
growth, proliferation, and metabolism in response to diverse stimuli. Two major parallel …
growth, proliferation, and metabolism in response to diverse stimuli. Two major parallel …