RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global
health burden affecting millions of people, with contemporary treatments offering limited …

The field of gene therapy has experienced an insurgence of attention for its widespread
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …

Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

During the past two decades, the clinical use of biopharmaceutical products has markedly
increased because of their obvious advantages over conventional small-molecule drug …

ABSTRACT Preclinical Research Doxorubicin (DOX) is commonly used for the treatment of
breast cancer and lymphoma. However, its clinical use has been severely limited due to …

The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …

Lung cancer is one of the most aggressive and deadliest health threats. There has been an
increasing interest in non-coding RNA (ncRNA) recently, especially in the areas of …

ABSTRACT Introduction Ionizable lipid nanoparticles (LNPs) have been proven to have high
encapsulation, cellular uptake, and effective endosomal escape and are therefore promising …

Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and
growth regulation. They are key regulators of important cellular pathways in the tumor …