Pathophysiological aspects of alcohol metabolism in the liver
J Hyun, J Han, C Lee, M Yoon, Y Jung - International journal of molecular …, 2021 - mdpi.com
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic
or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; …
or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; …
[HTML][HTML] Animal models of alcoholic liver disease: pathogenesis and clinical relevance
Alcoholic liver disease (ALD), a leading cause of chronic liver injury worldwide, comprises a
range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular …
range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular …
Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans
L Maccioni, B Gao, S Leclercq, B Pirlot, Y Horsmans… - Gut …, 2020 - Taylor & Francis
Background Animal data suggest a role of the gut-liver axis in progression of alcoholic liver
disease (ALD), but human data are scarce especially for early disease stages. Methods We …
disease (ALD), but human data are scarce especially for early disease stages. Methods We …
Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations
PP Lowe, C Morel, A Ambade, A Iracheta-Vellve… - Journal of …, 2020 - Springer
Background Chronic alcohol consumption is associated with neuroinflammation, neuronal
damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation …
damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation …
Liver kinase B1/AMP‐activated protein kinase‐mediated regulation by gentiopicroside ameliorates P2X7 receptor‐dependent alcoholic hepatosteatosis
X Li, Y Zhang, Q Jin, KL Xia, M Jiang… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose Regulating P2X7 receptor‐mediated activation of NLRP3
inflammasomes could be a therapeutic strategy to treat alcoholic hepatosteatosis. We …
inflammasomes could be a therapeutic strategy to treat alcoholic hepatosteatosis. We …
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice
H Fan, T Tu, X Zhang, Q Yang, G Liu, T Zhang… - Food and Chemical …, 2022 - Elsevier
Acute liver injury (ALI) is a common pathology of liver diseases caused by different kinds of
pathogenic factors including viral infection, alcohol intake, drugs, and chemical poisons …
pathogenic factors including viral infection, alcohol intake, drugs, and chemical poisons …
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation
Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related
deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced …
deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced …
Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance
HA Khan, MZ Ahmad, JA Khan, MI Arshad - Hepatobiliary & pancreatic …, 2017 - Elsevier
Background Liver inflammation or hepatitis is a result of pluripotent interactions of cell death
molecules, cytokines, chemokines and the resident immune cells collectively called as …
molecules, cytokines, chemokines and the resident immune cells collectively called as …
Confined cascade metabolic reprogramming nanoreactor for targeted alcohol detoxification and alcoholic liver injury management
Alcoholic liver injury (ALI) is the leading cause of serious liver disease, whereas current
treatments are mostly supportive and unable to metabolize alcohol directly. Here we report a …
treatments are mostly supportive and unable to metabolize alcohol directly. Here we report a …
Animal models of binge drinking, current challenges to improve face validity
Abstract Binge drinking (BD), ie, consuming a large amount of alcohol in a short period of
time, is an increasing public health issue. Though no clear definition has been adopted …
time, is an increasing public health issue. Though no clear definition has been adopted …