Information about normal hepatic glucose metabolism may help to understand pathogenic
mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism …

Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK).
GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of …

Importance Latino populations have one of the highest prevalences of type 2 diabetes
worldwide. Objectives To investigate the association between rare protein-coding genetic …

Interpretation of the colossal number of genetic variants identified from sequencing
applications is one of the major bottlenecks in clinical genetics, with the inference of the …

Insulin secretion from β cells of the pancreatic islets of Langerhans controls metabolic
homeostasis and is impaired in individuals with type 2 diabetes (T2D). Increases in blood …

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose
sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver …

Inflammation, including reactive oxygen species and inflammatory cytokines in tissues
amplify various post-translational modifications of self-proteins. A number of post …

Aims/hypothesis Post-translational attachment of a small ubiquitin-like modifier (SUMO) to
the lysine (K) residue (s) of target proteins (SUMOylation) is an evolutionary conserved …

Posttranslational protein modifications (PTMs) are an inherent response to physiological
changes causing altered protein structure and potentially modulating important biological …

Post-translational modification (PTM) has a significant impact on cellular signaling and
function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell …