Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast

JT Payne, TR Valentic… - Proceedings of the …, 2021 - National Acad Sciences
Benzylisoquinoline alkaloids (BIAs) are a diverse class of medicinal plant natural products.
Nearly 500 dimeric bisbenzylisoquinoline alkaloids (bisBIAs), produced by the coupling of …

In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves

JE Okokon, R Mobley, UA Edem, AI Bassey… - Scientific Reports, 2022 - nature.com
Abstract Saccharum officinarum Linn.(sugarcane, Family-Poaceae) is employed in Ibibio
traditional medicine for the treatment of various infections and diseases such as malaria. We …

Fatty Acid Esters and Acyclic Monoterpenoid from Justicia insularis Leaf Fractions Attenuated Malaria Pathogenesis Through Docking with Plasmodium falciparum …

VJ Enyiekere, EE Asanga, JE Okokon… - Natural Product …, 2024 - journals.sagepub.com
Background Justicia insularis (Acanthaceae) T. Anderson is ethnopharmacologically used in
Nigeria for the treatment of diseases including malaria. Therefore, this study was designed …

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

TM Dhameliya, DS Patel, D Kathuria, MB Shah… - …, 2024 - Wiley Online Library
Malaria remains a severe infectious disease caused by Plasmodium parasites among the
primarily afflicting impoverished populations. According to World Health Organization (WHO) …

Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells

IE Fadayomi, OR Johnson-Ajinwo, E Pires… - Molecules, 2021 - mdpi.com
Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics.
Drug discovery from edible and medicinal plants represents a promising approach towards …

Alkaloids as antimalarial compounds: a review of recent studies

NAUM Saufi, UUM Hatta, FNAA Rashid… - Mini-Reviews in …, 2023 - ingentaconnect.com
Malaria is a parasitic infection caused by Plasmodium parasites that are transmitted to
humans through the bite of infected Anopheles mosquitoes. Malaria continues to contribute …

Evaluation of antiplasmodial potential of Cissampelos pareira L.: Characterization and quantification of isoquinoline alkaloids responsible for the biological activity

S Kumari, P Agrawal, D Sahal, U Sharma - South African Journal of …, 2024 - Elsevier
Globally, based on traditional knowledge, different parts of Cissampelos pareira plant are
being used individually or in combination in various forms to manage malaria. However, the …

Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger

J Luo, R Mobley, S Woodfine, F Drijfhout… - Applied Microbiology …, 2022 - Springer
Artemisinin is a component part of current frontline medicines for the treatment of malaria.
The aim of this study is to make analogues of artemisinin using microbial transformation and …

In silico pharmacology and bioavailability of bioactive constituents from Triclisia subcordata (Oliv), an underutilized medicinal plant in Nigeria

AD Ogunlakin, TR Onifade, GA Gyebi… - Plant Science …, 2023 - horizonepublishing.com
Medicinal plants are rich sources of traditional medicines from which many modern
medicines are made. Triclisia subcordata Oliv. is one among the underutilized medicinal …

Evaluation of Plasmodium berghei Models in Malaria Research

SO Otun, R Graca, O Onisuru… - Journal of Cellular …, 2024 - scientificarchives.com
As a key model organism for studying malaria, Plasmodium berghei provides essential
information on pathophysiology, host immunological responses, and possible targets for …