International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …
and various drugs in development. Their diversity of structure and function reflects the …
Adenosine-to-inosine RNA editing in neurological development and disease
Y Yang, S Okada, M Sakurai - RNA biology, 2021 - Taylor & Francis
ABSTRACT Adenosine-to-inosine (A-to-I) editing is one of the most prevalent post-
transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called …
transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called …
[HTML][HTML] Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors
RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter
protein function through modification of the amino acid content. The 5HT 2C serotonin …
protein function through modification of the amino acid content. The 5HT 2C serotonin …
Accurate identification of A-to-I RNA editing in human by transcriptome sequencing
RNA editing enhances the diversity of gene products at the post-transcriptional level.
Approaches for genome-wide identification of RNA editing face two main challenges …
Approaches for genome-wide identification of RNA editing face two main challenges …
RNA recoding in cephalopods tailors microtubule motor protein function
KJ Rangan, SL Reck-Peterson - Cell, 2023 - cell.com
RNA editing is a widespread epigenetic process that can alter the amino acid sequence of
proteins, termed" recoding." In cephalopods, most transcripts are recoded, and recoding is …
proteins, termed" recoding." In cephalopods, most transcripts are recoded, and recoding is …
Adar3 is involved in learning and memory in mice
D Mladenova, G Barry, LM Konen, SS Pineda… - Frontiers in …, 2018 - frontiersin.org
The amount of regulatory RNA encoded in the genome and the extent of RNA editing by the
post-transcriptional deamination of adenosine to inosine (AI) have increased with …
post-transcriptional deamination of adenosine to inosine (AI) have increased with …
Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model
J Hebras, V Marty, J Personnaz, P Mercier, N Krogh… - elife, 2020 - elifesciences.org
SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its
ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I …
ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I …
Serotonin-2C and-2a receptor co-expression on cells in the rat medial prefrontal cortex
Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition,
attention and impulse control, implicating neuroregulatory abnormalities within this region in …
attention and impulse control, implicating neuroregulatory abnormalities within this region in …
A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations
Background Adenosine-to-inosine (A-to-I) RNA editing is an epigenetic modification
catalyzed by adenosine deaminases acting on RNA (ADARs), and is especially prevalent in …
catalyzed by adenosine deaminases acting on RNA (ADARs), and is especially prevalent in …
Serotonin 2c receptor RNA editing in major depression and suicide
R Lyddon, AJ Dwork, M Keddache… - The world journal of …, 2013 - Taylor & Francis
Objectives. mRNA for serotonin 2C receptor (5-HT2CR) undergoes editing which results in
numerous isoforms. More highly edited isoforms exhibit decreased function. We recently …
numerous isoforms. More highly edited isoforms exhibit decreased function. We recently …