Genetic determinants of the interventricular septum are linked to ventricular septal defects and hypertrophic cardiomyopathy

M Yu, AR Harper, M Aguirre, M Pittman… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: A large proportion of genetic risk remains unexplained for structural heart
disease involving the interventricular septum (IVS) including hypertrophic cardiomyopathy …

Computational estimates of mitral annular diameter in systole and diastole cardiac cycle reveal novel genetic determinants of valve function and disease

M Yu, C Tcheandjieu, A Georges, K Xiao, H Tejeda… - medRxiv, 2020 - medrxiv.org
The fibrous annulus of the mitral valve defines the functional orifice and anchors the anterior
and posterior leaflets, playing an important role in normal cardiovascular physiology and …

Genetic determinants of interventricular septal anatomy and the risk of ventricular septal defects and hypertrophic cardiomyopathy

M Yu, AR Harper, M Aguirre, M Pittman, C Tcheandjieu… - medRxiv, 2021 - medrxiv.org
Background The interventricular septum (IVS) plays a primary role in cardiovascular
physiology and a large proportion of genetic risk remains unexplained for structural heart …