Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Inflammatory arthritis is a growing worldwide concern, afflicting millions of individuals and
leading to a depreciating quality of life, significant morbidity, and subsequent healthcare …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

Abstract Peptide arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues
on target proteins to citrulline residues in the presence of calcium ions. This particular …

Protein arginine deimination leading to the non-coded amino acid citrulline remains a key
question in the field of post-translational modifications ever since its discovery by Rogers …

Despite the high morbidity and mortality among patients with extensive cutaneous burns in
the intensive care unit due to the development of acute respiratory distress syndrome …

Protein citrullination plays a role in several autoimmune diseases. Its involvement in murine
and human type 1 diabetes has recently been recognized through the discovery of …