Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

Simple Summary Reprogramming metabolism is a hallmark of cancer. Warburg's effect,
defined as increased aerobic glycolysis at the expense of mitochondrial respiration in …

Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …

Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic
acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular …

The combination of the “correct” triterpenoid, the “correct” spacer and rhodamine B (RhoB)
seems to be decisive for the ability of the conjugate to accumulate in mitochondria. So far …

Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an
established antidiabetic drug, mildly inhibits mitochondrial complex I, while IACS‐010759 is …

Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …

Acute myeloid leukemia (AML) is a heterogeneous disease with variable presentation,
molecular phenotype, and cytogenetic abnormalities and has seen very little improvement in …