The ryanodine receptor (RyR) is a high-conductance Ca2+ channel of the sarcoplasmic
reticulum in muscle and of the endoplasmic reticulum in other cells. In striated muscle fibers …

The ryanodine receptor (RyR) c corresponds to the sarcoplasmic reticulum (SR) Ca2+
channel (Inui et al., 1987; Imagawa et al., 1987). Its structure and function have been …

The cardiac ryanodine receptor (RyR2)/calcium release channel on the sarcoplasmic
reticulum is required for muscle excitation-contraction coupling. Using site-directed …

▪ Abstract Intracellular calcium release channels are present on sarcoplasmic and
endoplasmic reticuli (SR, ER) of all cell types. There are two classes of these channels …

Channel adaptation is a fundamental feature of sarcoplasmic reticulum calcium release
channels (called ryanodine receptors, RyRs). It permits successive increases in the …

Complexities in calcium signaling in eukaryotic cells require diversity in the proteins
involved in generating these signals. In this review, we consider the ryanodine receptor …

1 To assess the specific functions of the cardiac isoform of troponin I (cTnI), we produced
transgenic mice that expressed slow skeletal troponin I (ssTnI) specifically in …

1 Electromechanical alternans was characterized in single cat atrial and ventricular
myocytes by simultaneous measurements of action potentials, membrane current, cell …

Subcellular Ca2+ signalling during normal excitation‐contraction (E‐C) coupling and during
Ca2+ alternans was studied in atrial myocytes using fast confocal microscopy and …

Protein kinases play important roles in intracellular signalling pathways in probably all cells.
In the heart, they are involved in the regulation of ion handling, contractility, fuel metabolism …