The extracellular matrix (ECM) is a dynamic structural network that provides a physical
scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus …

In this comprehensive review, we will dissect the impact of research on proteoglycans
focusing on recent developments involved in their synthesis, degradation, and interactions …

Although UVB radiation is mainly absorbed by the epidermis,~ 5–10% of its photons reach
and affect the upper part of the dermis. Physiologically relevant UVB doses, able to provoke …

The aim of the present study was to provide a comprehensive characterization of whole
genome DNA methylation patterns in replicative and ionizing irradiation-or doxorubicin …

Biglycan is a class I secreted small leucine-rich proteoglycan (SLRP), which regulates
signaling pathways connected to bone pathologies. Autophagy is a vital catabolic process …

Simple Summary The eminent rise of extracellular matrix constituents, chiefly hailing from
the proteoglycan gene family, has revolutionized our understanding of how intracellular …

Ultraviolet B (UVB) radiation is a major contributor to skin photoaging. Although mainly
absorbed by the epidermis, UVB photons managing to penetrate the upper dermis affect …

Colorectal cancer cells can transfer the oncogene KRAS to distant cells, predisposing them
to malignant transformation (Genometastasis Theory). This process could contribute to liver …

The human xylosyltransferase isoform XT-I catalyzes the initial step in proteoglycan
biosynthesis and represents a biomarker of myofibroblast differentiation. Furthermore, XT-I …

Radiotherapy is widely used for the treatment of breast cancer. However, we have shown
that ionizing radiation can provoke premature senescence in breast stromal cells. In …