The gastrointestinal tract is the only internal organ to have evolved with its own independent
nervous system, known as the enteric nervous system (ENS). This Review provides an …

The brain-gut axis allows bidirectional communication between the central nervous system
(CNS) and the enteric nervous system (ENS), linking emotional and cognitive centers of the …

The microbiota-gut-brain axis transmits bidirectional communication between the gut and
the central nervous system and links the emotional and cognitive centers of the brain with …

Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of
the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease …

Background The use of the anticancer chemotherapeutic agent 5‐fluorouracil (5‐FU) is often
limited by nausea, vomiting, constipation, and diarrhea; these side‐effects persist long after …

While the clinical importance of human rotavirus (RV) disease is well recognized and potent
vaccines have been developed, our understanding of how human RV causes diarrhoea …

The Winnie mouse, carrying a missense mutation in Muc2, is a model for chronic intestinal
inflammation demonstrating symptoms closely resembling inflammatory bowel disease …

Background Enterochromaffin (EC) cell‐derived 5‐hydroxytryptamine (5‐HT) is a mediator
of toxin‐induced reflexes, initiating emesis via vagal and central 5‐HT3 receptors. The …

Key points Cholera causes more than 100,000 deaths each year as a result of severe
diarrhoea, vomiting and dehydration due to the actions of cholera toxin; more females than …

Segmentation is an important process in nutrient mixing and absorption; however, the
mechanisms underlying this motility pattern are poorly understood. Segmentation can be …