Mouse models of sarcopenia: classification and evaluation

W Xie, M He, D Yu, Y Wu, X Wang, S Lv… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

Redox signaling and sarcopenia: searching for the primary suspect

NA Foreman, AS Hesse, LL Ji - International journal of molecular sciences, 2021 - mdpi.com
Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …

A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial

A Karim, T Muhammad, MS Iqbal, R Qaisar - Archives of gerontology and …, 2022 - Elsevier
Purpose The age-related muscle loss, termed sarcopenia and functional dependency, are
common findings in patients with chronic obstructive pulmonary disease (COPD). However …

Elevated plasma zonulin and CAF22 are correlated with sarcopenia and functional dependency at various stages of Alzheimer's diseases

A Karim, MS Iqbal, T Muhammad, F Ahmad… - Neuroscience …, 2022 - Elsevier
Age-related muscle decline, termed sarcopenia, is closely linked to dementia; however, its
causative factors in patients with Alzheimer's disease (AD) are poorly characterized. We …

[HTML][HTML] Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive …

S Bhaskaran, G Kumar, N Thadathil, KM Piekarz… - Redox Biology, 2023 - Elsevier
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease.
Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord …

Targeting neuromuscular junction to treat neuromuscular disorders

R Qaisar - Life Sciences, 2023 - Elsevier
The integrity and preservation of the neuromuscular junction (NMJ), the interface between
the motor neuron and skeletal muscle, is critical for maintaining a healthy skeletal muscle …

Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation

H Xu, B Ahn, H Van Remmen - Science Advances, 2022 - science.org
Muscle weakness associated with sarcopenia is a major contributor to reduced health span
and quality of life in the elderly. However, the underlying mechanisms of muscle weakness …

Prediction of sarcopenia using multiple biomarkers of neuromuscular junction degeneration in chronic obstructive pulmonary disease

A Karim, T Muhammad, R Qaisar - Journal of Personalized Medicine, 2021 - mdpi.com
Patients with chronic obstructive pulmonary disease (COPD) present with an advanced form
of age-related muscle loss or sarcopenia. Among multiple pathomechanisms of sarcopenia …

[HTML][HTML] Elevated plasma CAF22 are incompletely restored six months after COVID-19 infection in older men

A Karim, T Muhammad, MS Iqbal, R Qaisar - Experimental Gerontology, 2023 - Elsevier
Introduction The long-term complications of COVID-19 appear as significant health
problems. However, the long-term muscle decline in these patients is poorly characterized …

[HTML][HTML] Ginseng and ginsenosides: Therapeutic potential for sarcopenia

W Zha, Y Sun, W Gong, L Li, W Kim, H Li - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Sarcopenia is a progressive syndrome that results in a decline in skeletal muscle mass and
strength. This affects patients' quality of life and increases the risk of falls and fractures …