Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted
interest in its role in cancer biology and potential as a therapeutic target. Decreased …

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by
nearly all cells of the body. It plays an integral role in various immune responses as well as …

Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …

Inflammation is a defensive process against tissue injury. Once this self‐protective strategy
is initiated, an effective resolution of the process is crucial to avoid major and unnecessary …

Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

The development of cancer involves mechanisms by which aberrant cells overcome normal
regulatory pathways that limit their numbers and their migration. The evasion of programmed …

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …

CD47 is a widely expressed integral membrane protein that serves as the counter-receptor
for the inhibitory phagocyte receptor signal-regulatory protein-α (SIRPα) and as a signaling …

Variants of the CFH gene, encoding complement factor H (CFH), show strong association
with age-related macular degeneration (AMD), a major cause of blindness. Here, we used …