The non-coding RNA interactome in joint health and disease

SA Ali, MJ Peffers, MJ Ormseth, I Jurisica… - Nature Reviews …, 2021 - nature.com
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

The regulatory activities of MALAT1 in the development of bone and cartilage diseases

D Zhang, J Xue, F Peng - Frontiers in Endocrinology, 2022 - frontiersin.org
Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various
cellular functions by mediating transcriptional or post-transcriptional activities. MALAT1 is …

The emerging role of lncRNAs in osteoarthritis development and potential therapy

X Zhang, Q Liu, J Zhang, C Song, Z Han, J Wang… - Frontiers in …, 2023 - frontiersin.org
Osteoarthritis impairs the functions of various joints, such as knees, hips, hands and spine,
which causes pain, swelling, stiffness and reduced mobility in joints. Multiple factors …

LncRNAs as a new regulator of chronic musculoskeletal disorder

H Huang, D Xing, Q Zhang, H Li, J Lin, Z He… - Cell …, 2021 - Wiley Online Library
Objectives In recent years, long non‐coding RNAs (lncRNAs) have been found to play a role
in the occurrence, progression and prognosis of chronic musculoskeletal disorders. Design …

Emerging role of lncRNAs in osteoarthritis: An updated review

R Wang, HT Shiu, WYW Lee - Frontiers in immunology, 2022 - frontiersin.org
Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular
cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The …

Unraveling the Molecular Landscape of Osteoarthritis: A Comprehensive Review Focused on the Role of Non-Coding RNAs

M Shakeri, A Aminian, K Mokhtari, M Bahaeddini… - … -Research and Practice, 2024 - Elsevier
Osteoarthritis (OA) poses a significant global health challenge, with its prevalence
anticipated to increase in the coming years. This review delves into the emerging molecular …

Plasma LncRNA MALAT1 expressions are negatively associated with disease severity of postmenopausal osteoporosis

TY Qian, H Wan, CY Huang, XJ Hu… - Laboratory …, 2022 - academic.oup.com
Background Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1
(LncRNA MALAT1) has been proven to promote osteogenesis in different health conditions …

Long non-coding RNAs as emerging regulators of miRNAs and epigenetics in diabetes-related chronic kidney disease

V Shelke, A Kale, H Sankrityayan… - … of Physiology and …, 2024 - Taylor & Francis
Diabetes is one of the major cause of chronic kidney disease (CKD), including “diabetic
nephropathy,” and is an increasingly prevalent accelerator of the progression of non …

Depicting pathogenesis of osteomyelitis by single cell RNA-sequencing and an involvement of Morrbid in the autoinflammatory disease

Q Huo, J Ding, H Zhou, H He, LC Cai, J Liu, G Dong… - bioRxiv, 2025 - biorxiv.org
Autoinflammatory diseases (AIDs) are defined as abnormal activation of the innate immune
system leading to spontaneous and uncontrolled inflammation. The AIDs affect bone tissue …

LncRNA linc00641 Inhibits the Proliferation and Differentiation of Chondrocytes and Aggravates Joint Injury by Targeting miR-320a

SY Han, H Liu, Y Wang, SY Wang, B Yang… - Russian Journal of …, 2024 - Springer
The purpose of this study was to investigate the expression of long non-coding RNA
linc00641 in OA and its biological function in osteoarthritis (OA). The expression level of …