The advent of next generation sequencing (NGS) technologies has revolutionized the field
of genomics, enabling fast and cost-effective generation of genome-scale sequence data …

MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal
plasma. An increasing number of studies have been published on the cellular origin …

Late diagnosis contributes to pancreatic cancer (PaCa) dismal prognosis, urging for reliable,
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …

Purpose: There is a quest for novel noninvasive diagnostic markers for the detection of
breast cancer. The goal of this study is to identify circulating microRNA (miRNA) signatures …

Atypical miRNA substrates do not fit criteria often used to annotate canonical miRNAs, and
can escape the notice of miRNA genefinders. Recent analyses expanded the catalogs of …

Ductal carcinoma in situ (DCIS) is a noninvasive precursor lesion to invasive breast
carcinoma. We still have no understanding on why only some DCIS lesions evolve to …

Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic
strategy for KRAS-driven tumors. In this study, we exploited the power of the CRISPR-Cas9 …

PIWI-interacting small non-coding RNAs (piRNAs) are genetic and epigenetic regulatory
factors in germline cells, where they maintain genome stability, are involved in RNA …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and has
profound impacts on the daily lives of patients. However, there is a lack of effective …

Background Accurate classification of breast cancer using gene expression profiles has
contributed to a better understanding of the biological mechanisms behind the disease and …