Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

Background Smoking is one of the leading causes of millions of deaths worldwide. During
cigarette smoking, most affected and highly exposed cells are the alveolar epithelium and …

The tissue composition of polyunsaturated fatty acids is important to health and depends on
both dietary intake and metabolism controlled by genetic polymorphisms that should be …

After the successful development of antibiotics and the improvement of nutritional and
hygienic conditions, mortalities from infectious diseases have decreased, and chronic …

Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the
oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) …

Mounting evidence suggests that lipoxygenase (LO)-catalyzed products have a profound
influence on the development and progression of human cancers. Compared with normal …

5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …