N-Methyl-d-aspartate (NMDA) receptors are tetrameric ion channels containing two of four
possible GluN2 subunits. These receptors have been implicated for decades in neurological …

Out of several heterocyclic templates, the use of a Benzimidazole (BZ) scaffold is immensely
observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd …

Schizophrenia is a highly debilitating mental disorder which afflicts approximately 1% of the
global population. Cognitive and negative deficits account for the lifelong disability …

The unique structural and physicochemical properties of adamantane and its derivatives
have attracted considerable attention in the field of medicinal chemistry. Substituting phenyl …

Supramolecular studies of iminoisoindoline-derived compounds have been prompted by
their biological and photophysical properties. In this article, we report the synthesis …

GluN2B subunit containing NMDARs (GluN2B-NMDARs) mediate pathophysiological effects
of acutely applied amyloid beta (Aβ), including impaired long-term potentiation (LTP) …

GluN2B subtype-selective NMDA antagonists represent promising therapeutic targets for the
symptomatic treatment of multiple CNS pathologies. A series of N-benzyl substituted …

The role of the N-methyl-d-aspartate receptor (NMDAr) as a contributor to maladaptive
neuroplasticity underlying the maintenance of chronic pain is well established. Agmatine, an …

Diastereoisomeric compounds [18F] cis-and [18F] trans-4-methylbenzyl 4-[(pyrimidin-2-
ylamino) methyl]-3-fluoro-piperidine-1-carboxylates were successfully synthesized as new …

Glutamate N-methyl-D-aspartate (NMDA) receptors are widely distributed throughout the
mammalian central nervous system (CNS). They play key roles in many brain disorders …