Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One
of the pivotal contributions of autophagy in immunity is the cell autonomous control of …

In a somewhat narrow diagnostic lens, Alzheimer disease (AD) has been considered a brain-
specific disease characterized by the presence of Aβ (β-amyloid) plaques and tau neural …

Cells compartmentalize biochemical reactions using organelles. Organelles can be either
membrane-bound compartments or supramolecular assemblies of protein and ribonucleic …

Background: Individually, heart failure (HF) and Alzheimer's disease (AD) are severe threats
to population health, and their potential coexistence is an alarming prospect. In addition to …

This review summarises 25 years of investigations on antioxidants research in foods and
biological fluids and critically analyses the merits and limitations of using the total …

Crystallopathies | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal
damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system …

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Protein conformation and cell compartmentalization are fundamental concepts and subjects
of vast scientific endeavors. In the last two decades, we have witnessed exciting advances …